Murphy also voiced Luanne Platter on the animated television series King of the Hill (1997–2009).
Her final film, Something Wicked, was released in April 2014.
Her task was to read the names of the five nominees, open an envelope, and reveal the name of the winner.
This she turned into an opportunity for screwball improvisational comedy, by pretending she could not follow this sequence, not even after the audience shouted instructions and the stage manager came to whisper in her ear not once but twice.
I've just always kept it a secret and never taken credit because I wanted to learn how to work behind the microphone in a recording studio, and some of the singers don't even know it was me recording on their albums." She was in a band called Blessed Soul with fellow actor Eric Balfour in the early 1990s.
On June 6, 2006, Murphy and Paul Oakenfold released the single "Faster Kill Pussycat", from the album A Lively Mind.
In November 2009, Murphy left the production of The Caller, which was being filmed in Puerto Rico, and was replaced by Rachelle Lefevre.
Murphy denied media reports that she had been fired from the project after being difficult on set, and cited "creative differences". She commented: "My singing voice isn't like my speaking voice...
The song became a club hit and hit number one on Billboard She dabbled in music again with the release of the film Happy Feet, in which she covered Queen's "Somebody to Love" and Earth, Wind & Fire's "Boogie Wonderland".
Murphy said about her character, Gloria, "Oddly enough, of all the characters I've played, Gloria is the most like me. George Miller always wanted one person to do both [the speaking and the singing].
She was nominated for an Annie Award for voice acting in the King of the Hill episode "Movin' On Up".
She began the 2000s with a leading role in Don't Say a Word (2001) alongside Michael Douglas; the TV adaptation of the novel The Devil's Arithmetic (2001); 8 Mile (2002), for which she received critical acclaim; and Uptown Girls (2003).
In 2003, she starred in the romantic comedies Just Married and Little Black Book (2004) and the critically acclaimed Sin City (2005).